Characterization of protein tyrosine phosphatase H1 knockout mice in animal models of local and systemic inflammation.

At 180 mpt, both PTPH1-WT and KO LPS-treated mice showed a highly significant increase of TNFα expression in whole white cells compared to vehicle-treated animals (4.9 and 7.3 fold respectively) (PTPH1-KO LPS vs vehicle; P KO 180 mpt < 0.001; PTPH1-WT LPS vs vehicle; P WT 180 mpt < 0.01; Figure 5c ).

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Comparatively, Catwalk gait analysis showed a trend of slightly earlier onset (5 h after injection) of spontaneous pain perception indicated as print area (Figure 3a ) and duty cycle (Figure 3b ) in PTPH1-KO mice, compared to matched WTs.

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