Risk of type 2 diabetes and obesity is differentially associated with variation in FTO in whites and African-Americans in the ARIC study.

Another possibility is that if the relationship between FTO sequence variation and diabetes is at least partially mediated by BMI, the nominally significant p-value found for the association of rs1421085 with obesity and the absence of association for the remaining variants in African-Americans may make an increase in diabetes susceptibility more difficult to detect.

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