Genetics of Alzheimer disease in the pre- and post-GWAS era.

Alzheimers Res Ther · 2010 · PMC2874262 · PMID 20236449

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

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boldest claim

The sentences

nominally significantP = 4.56 × 10 -7actually significant

They identified 10 SNPs in the GRB-associated binding protein 2 ( GAB2 ) gene on chromosome 11q14.1 with nominally significant associations ( P = 4.56 × 10 -7 to 8.92 × 10 -5 ) in the APOE ε4 carrier subset of the neuropathological discovery cohort composed of 299 LOAD patients and 61 controls.

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highly significantno p-value reported

In these two studies, this was the case with the APOE SNPs that were highly significant in each study but could not be imputed in the other study, leading to missing the APOE signal in the joint analyses.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.