Birth order modifies the effect of IL13 gene polymorphisms on serum IgE at age 10 and skin prick test at ages 4, 10 and 18: a prospective birth cohort study.

Allergy Asthma Clin Immunol · 2010 · PMC2874524 · PMID 20403202

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showed a trendno p-value reported

Among first-born children, minor allele carrier-ship of rs20541 showed a trend towards a higher risk of skin sensitization at age 4 (PR = 1.59; 95% CI = 1.01, 2.50), age 10 (PR = 1.48; 95% CI = 0.99, 2.20) and 18 years (PR = 1.21; 95% CI = 0.86, 1.69).

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borderline significanceno p-value reported

The stratified analysis showed that the effect of IL13 on SPT at ages 4, 10 and 18 was evident only among first-born children (p = 0.007; adjusted PR = 1.35; 95% CI = 1.09, 1.69), with borderline significance for second-born children.

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