Bcl-2 has been found to mediate the anti-apoptotic effect of nicotine in lung cancer [ 44 ] and we observed higher Bcl-2 expression in tumors of smokers (n = 265) compared to non smokers (n = 29; mean ± SE 30.8 ± 2.1 and 22.7 ± 2.96 respectively; data not shown) however this did not reach statistical significance due to small number of non smokers.
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High expression of BCL-2 predicts favorable outcome in non-small cell lung cancer patients with non squamous histology.
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