Expression analysis of genes associated with human osteosarcoma tumors shows correlation of RUNX2 overexpression with poor response to chemotherapy.

MYC , BMP2 , and FOS show an associative trend when overexpressed, and TNFRSF10A shows a trend in underexpression in the tumor cohort.

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Interestingly, in our recent study we showed that DOCK5 is located in the most significant region of copy number loss in osteosarcoma 8p21.2-p21.3 [ 19 ] along with the TNFRSF10A gene, for which we see an overall trend of loss of expression in our current study.

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Furthermore, RUNX2 expression showed a trend towards overexpression going from normal osteoblasts to favorable responders to chemotherapy and then to unfavorable responders to chemotherapy (Figure 1 ).

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