Novel use of glucagon in a closed-loop system for prevention of hypoglycemia in type 1 diabetes.

There was a reduction in the number of treatments for hypoglycemia in studies with low-gain glucagon of borderline significance (1.0 ± 0.7 vs. 3.9 ± 1.0 treatments/day, P = 0.05).

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There was also a trend toward a reduction in the number of hypoglycemic events that did not reach statistical significance (1.4 ± 0.7 vs. 2.3 ± 0.5 events/day, P = NS).

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There was a nonsignificant trend toward a higher postprandial glucose in high-gain glucagon versus placebo studies, defined as mean value 0–180 min after meals (157 ± 18 vs. 144 ± 17 mg/dl, P = NS).

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