Aging and chronic sun exposure cause distinct epigenetic changes in human skin.

PLoS Genet · 2010 · PMC2877750 · PMID 20523906

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highly significantno p-value reported

Importantly, global age-related and sun exposure-related DNA methylation shifts were highly significant when compared to Gaussian distributions of randomly generated methylation differences and after a global Benjamini-Hochberg adjustment of the P-values ( Figure 4D ).

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a significant trendno p-value reported

Interestingly, stratification by sun exposure produced a fundamentally different pattern with a significant trend towards hypomethylation.

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