only marginally significantP < 0.001
For HP, a significant reduction was observed at 12 months but was only marginally significant at 24 months, probably due to the large between-patient variation (IQR = 13% at 24 months versus 6.7% at 12 months) (median decrease of BMD by -2.4%, P < 0.001 and -5.7%, P = 0.09, respectively); however, only 11 patients (22%) became osteopenic and 2 (4%) became osteoporotic.