Deletion of inducible nitric-oxide synthase in leptin-deficient mice improves brown adipose tissue function.

Deletion of iNOS slightly decreased the weight of BAT in wild type (wild type 0.31±0.02, iNOS − / − 0.29±0.01 g/100 g body weight) and ob/ob mice ( ob/ob 0.80±0.04, DBKO 0.75±0.04 g/100 g body weight) although the differences did not reach statistical significance ( Fig. 2B ).

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