Novel HSP90 inhibitors, NVP-AUY922 and NVP-BEP800, radiosensitise tumour cells through cell-cycle impairment, increased DNA damage and repair protraction.

The reduction of Akt, however, did not reach statistical significance in the case of HT 1080 cells, whereas in the other tested cell lines, the level of Akt decreased significantly ( Supplementary Figure S1 ).

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