A clear trend towards an up-regulation of chemokines involved in attraction of Th1 cells ( Cxcl9 , Cxcl10 and Cxcl11 ) and/or monocytes/macrophages ( Ccl3 , Ccl4 , Ccl7 and Ccl12 ) upon stimulation with L. acidophilus NCFM emerged, whereas B. bifidum Z9 gave rise to a much lower gene induction of Th1 recruiting chemokines (55% reduction of Cxcl9 , 44% reduction of Cxcl10 and 73% reduction of Cxcl11 compared to DC stimulated with L. acidophilus NCFM ).
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Bifidobacterium bifidum actively changes the gene expression profile induced by Lactobacillus acidophilus in murine dendritic cells.
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