Platelet-derived growth factor and transforming growth factor beta synergistically potentiate inflammatory mediator synthesis by fibroblast-like synoviocytes.

In contrast, the PI3K inhibitor, LY294002 had a significant effect on the IL6 expression induced by 2GF alone or TNFα alone, but in the case of the combination the effect, although evident, did not reach statistical significance (Figure 7a ).

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