Specifically, there was a decrease in median IFN-γ responses to ESAT-6 and CFP-10 and an increase in the response to PPD following six months of anti-tuberculous treatment, though the change in response to PPD failed to reach statistical significance (ESAT-6 median 110 SFCs/10 6 PBMC (IQR 65-305) vs. 15 (10-115), p = 0.04; CFP-10 177 (48-508) vs. 20 (5-165), p = 0.004; PPD 155 (82-307) vs. 515 (45-1010), p = 0.12).
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Reversion and conversion of Mycobacterium tuberculosis IFN-gamma ELISpot results during anti-tuberculous treatment in HIV-infected children.
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