Genetic modulation of GABA levels in the anterior cingulate cortex by GAD1 and COMT.

COMT Val158Met was also nominally significant in this model (F (2,109) =3.4, p =0.04) (but see below for other model results).

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The interaction effect for the model including rs11542313, COMT , and age (main effect of rs11542313: F (1,106) =10.6, p <0.0015 and COMT : F (2,106) =6.09, p <0.003) showed a trend toward significance (F (2,106) =3.03, p =0.05: Supplementary Table S2, corrections for multiple comparisons would require at least a p -value of 0.017).

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The interaction effect for the model including rs11542313, COMT , and age (main effect of rs11542313: F (1,106) =10.6, p <0.0015 and COMT : F (2,106) =6.09, p <0.003) showed a trend toward significance (F (2,106) =3.03, p =0.05: Supplementary Table S2, corrections for multiple comparisons would require at least a p -value of 0.017).

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