GW501516 - and PF-879-treated mice exhibited lower fasting insulin concentrations compared to vehicle; however, the differences failed to reach statistical significance (mean ± SE; Veh = 19.46±2.61, GW501516 = 13.91±2.45, PF-879 = 14.76±1.43, GW501516 +PF-879 = 18.58±2.72 ng/ml; ANOVA p = 0.26).
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Postnatal PPARdelta activation and myostatin inhibition exert distinct yet complimentary effects on the metabolic profile of obese insulin-resistant mice.
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