Skeletal muscle excitation-contraction coupling is independent of a conserved heptad repeat motif in the C-terminus of the DHPRbeta(1a) subunit.

Both β 1a AAA mutants induced a small shift in the voltage-dependence of intracellular Ca 2+ transients towards more positive potentials, that was slightly significant ( p = 0.036) for zf-β 1a AAA (8.94 ± 2.32 mV; n = 14) compared to zf-β 1a (−0.06 ± 3.49 mV; n = 9), but highly significant ( p = 0.003) for rb-β 1a AAA (7.56 ± 0.97 mV; n = 41) in comparison to rb-β 1a (1.69 ± 1.81 mV; n = 23).

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