Methylnaltrexone: the evidence for its use in the management of opioid-induced constipation.

Core Evid · 2010 · PMC2899781 · PMID 20694079

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did not reach statistical significanceno p-value reported

The time to toleration of full liquids, solid foods, and actual discharge were reduced, which favors treatment, but these effects did not reach statistical significance. 57 Further randomized controlled studies are currently under way to clarify the impact of methylnaltrexone.

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