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The human gonadotropin releasing hormone type I receptor is a functional intracellular GPCR expressed on the nuclear membrane.

PLoS One · 2010 · PMC2900216 · PMID 20628612

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showed a trendno p-value reported
Nevertheless, both mutants showed a trend towards an increase in IP formation relative to the non-mutated receptor ( Fig. 3E ).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.