Gastrocnemius muscle isolated from ERRγ transgenic mice exhibited decreased expression of MHC IIb and a concomitant increase in expression of MHC IId and MHC IIa and a trend toward an increase in slow MHC I, which did not reach statistical significance ( Fig. 3 E ).
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Estrogen-related receptor gamma is a key regulator of muscle mitochondrial activity and oxidative capacity.
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