Clinicopathological features and outcome in advanced colorectal cancer patients with synchronous vs metachronous metastases.

In the effect on median OS a significant trend was observed for the following pathological characteristics of the primary tumour: T4 vs T3 vs T1-2 (14.3 vs 18.9 vs 21.9 months, respectively; P =0.03), N2 vs N1 vs N0 (14.4 vs 18.9 vs 20.7 months, respectively; P =0.003), mucinous carcinoma vs adenocarcinoma with mucinous component vs adenocarcinoma (13.5 vs 13.7 vs 19.3 months, respectively; P =0.006) and differentiation grade poor vs moderate vs well (14.8 vs 20.4 vs 24.9 months, respectively; P =0.0001).

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