Alterations in LMTK2, MSMB and HNF1B gene expression are associated with the development of prostate cancer.

CTBP2(1) and CTBP2(4) transcripts showed a trend towards lower expression in prostate cancer subjects treated with hormone therapy ( CTBP2(1) ; (0.87 [0.40] in untreated subjects versus 0.31[IQR0.17]; p = 0.006) and CTBP2(4) transcripts (1.01[IQR 0.99] in untreated subjects versus 0.45 [IQR0.42] in treated subjects; p = 0.006) but these results do not reach statistical significance following adjustment for multiple testing (P = < 0.004 for 12 independent tests).

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We found highly significant disturbances to the profile of isoforms expressed in prostate cancer in the case of the MSMB and HNF1B genes.

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