Autonomic neuropathy predisposes to rosiglitazone-induced vascular leakage in insulin-treated patients with type 2 diabetes: a randomised, controlled trial on thiazolidinedione-induced vascular leakage.

For example, the PROspective pioglitAzone Clinical Trial In macroVascular Events (PROActive) study showed a trend towards a reduced risk of cardiovascular events with pioglitazone compared with placebo in persons with type 2 diabetes, but this benefit was largely offset by fluid-related adverse events, oedema formation and heart failure [ 8 ].

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