Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD.

In models adjusting for cigarettes-per-day, we confirm the association between rs16969968 and lung cancer (p<10 −20 ) and observe a nominally significant association with COPD (p = 0.01); the other loci are not significantly associated with either lung cancer or COPD after adjusting for rs16969968.

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Meta-analysis across all 34 samples clearly shows a highly significant association between dichotomous CPD and locus 1 (tagging rs16969968).

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The minor allele at locus 3 shifts from a marginally significant protective factor when considered alone to a robust risk factor when considered in combination with locus 1.

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