5, 10, 15, 20 years) and different methods of forming quartiles (based on case exposures or entire cohort exposures) showed no significant positive trends at the p = 0.05 level, but the analysis using a 10-year lag and quartiles formed based on the PFOA distribution of the entire cohort did suggest a positive trend [risk ratios (RRs) = 1.0, 1.0, 1.4, and 1.6; p for trend = 0.06].
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Epidemiologic evidence on the health effects of perfluorooctanoic acid (PFOA).
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The sentences
There was a negative trend in diabetes occurrence by increasing serum PFOA decile (ORs = 1.00, 0.71, 0.60, 0.72, 0.65, 0.65, 0.87, 0.58, 0.62, 0.72).
Trends were of borderline significance for prostate cancer and pancreatic cancer and were absent or negative for bladder and liver cancer.