Radiographic severity of knee osteoarthritis is conditional on interleukin 1 receptor antagonist gene variations.

Although both populations were modest in size, these findings are unlikely to be false positives because ( a ) statistically significant associations were observed for multiple SNPs in the same gene, IL1RN, whereas no associations were found for SNPs in other genes; ( b ) a specific IL1RN haplotype was protective in two independent populations and with two different severity parameters; ( c ) in the combined dataset, associations with severity were highly significant (p<0.0001).

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Patients carrying the IL1RN CTA haplotype had significantly lower SF mean levels of IL10 (p=0.034), and showed a trend towards lower levels of IL1β and IL6 ( table 4 ).

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