Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system.

Interestingly, chronic JZL184 treatment exerted only a modest effect that did not reach statistical significance on CP55,940-induced depression of IPSCs in the caudate putamen ( Supplementary Fig. 12 ), a brain region that also showed minimal CB 1 receptor adaptations ( Fig. 5 ).

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