No observable difference was apparent between the amount of Scrib, Vangl2 or Celsr1 protein expressed in chuzhoi homozygous embryos, compared to wild-type littermates (Figure 12B-D ).
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The novel mouse mutant, chuzhoi, has disruption of Ptk7 protein and exhibits defects in neural tube, heart and lung development and abnormal planar cell polarity in the ear.
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