Moreover, in patients who had experienced a previous stroke six months or more before randomization, there was a significant 47% reduction (HR 0.53; P = .0085) of fatal or nonfatal stroke and a marginally significant 28% reduction (HR 72; P = .0467) of the composite end point of cardiovascular death, nonfatal MI, or nonfatal stroke (PROactive 04) [ 87 ].
Meanwhile, it has been reported that rosiglitazone treatment is associated with overall increased incidence of MI (OR 1.43; P = .03) and a potential increase of borderline significance in the risk of death from total CV causes (OR 1.64; P = .06) by meta-analysis [ 90 ].
Conversely, a pooled analysis of 3 large rosiglitazone trials designed to specifically test CV outcomes (a diabetes outcome progression trial, rosiglitazone evaluated for cardiac outcomes and regulation of glycemia in diabetes, and diabetes reduction assessment with ramipril and rosiglitazone medication) did not reach statistical significance for either MI (OR 1.29; P = .12) or death due to CV causes (OR 0.90; P = .67) [ 95 ].