Effect of increased enteral nutrition on ICU-acquired infections: a multicenter observational study

In the overall analysis, greater amounts of energy and protein were consistently associated with a reduction in infection but only achieved levels near statistical significance when considering the incremental effect of 1,000 kcal/day and 30 g/day on patients with at least one probable infection after >96 hours (odds ratio (OR) 0.32, 95% confidence interval (CI), 0.10 to 1.03, P = 0.055 and OR 0.41, 95% CI 0.19 to 0.89, P = 0.024 for energy and protein, respectively).

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