Association of a rheumatoid arthritis susceptibility variant at the CCL21 locus with premature mortality in inflammatory polyarthritis patients.

Increased risk of CVD mortality and carriage of the CCL21 risk allele was also seen in those who were anti-CCP antibody negative, although it did not reach statistical significance (HR for 1 or 2 copies versus 0 copies 1.45, 95% CI 0.99–2.12), and was higher in those who were anti-CCP antibody positive (HR 2.36, 95% CI 1.54–3.61).

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