Barely Significant
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Regulatory T cell frequency in patients with melanoma with different disease stage and course, and modulating effects of high-dose interferon-alpha 2b treatment.

J Transl Med · 2010 · PMC2936304 · PMID 20712892

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a clear trendno p-value reported
Although a clear trend for a reduction in Treg levels with HDI induction therapy in patients with melanoma was observed, statistical significance was not reached.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.