reported that patients receiving placebo were equally likely to withdraw owing to adverse events as were those receiving antimuscarinics (RR 1.01, 95% CI, 0.78–1.31).[ 58 ] In the Chapple meta-analysis, the RR (95% CI) for all-cause withdrawals was significantly greater in patients receiving oxybutynin IR (8.8–15.0 mg/day, 1.40, 1.06–1.84) compared with placebo and the risk of all-cause withdrawal for patients receiving tolterodine ER (0.71, 0.51–0.99) was significantly less than placebo.[ 59 ] The difference with other antimuscarinic agents and placebo did not reach statistical significance Tolterodine IR was found to cause fewer withdrawals due to adverse events than oxybutynin IR and; tolterodine ER caused fewer than both oxybutynin IR and transdermal oxybutynin.
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