Emerging treatments in the management of schizophrenia - focus on sertindole.

For both conventional and atypical antipsychotics, the risk of sudden cardiac death increased with an increasing dose; moreover, there was a dose-response trend for each of the six frequently prescribed drugs (haloperidol, thioridazine, clozapine, olanzapine, quetiapine, and risperidone), a trend that was significant in the case of thioridazine ( P = 0.005) and of borderline significance in the case of risperidone ( P = 0.05). 82 Tiihonen et al 83 have recently concluded a populationbased cohort study (FIN11 study) consisting of an 11-year follow-up of mortality in 66881 Finnish patients with schizophrenia treated with first- and second-generation antipsychotics.

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48 At primary endpoint, time to treatment failure was numerically superior in sertindole-treated patients compared to haloperidol-treated patients, even if this difference did not reach statistical significance.

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