Cardiovascular risk associated with interactions among polymorphisms in genes from the renin-angiotensin, bradykinin, and fibrinolytic systems.

However, by making some simplifying assumptions, and noting that a total of 105 interactions were tested (nine possible interaction effects were tested for the 15 possible pairs of polymorphisms minus 30 interactions since only dominant coding was used for the BDKRB2 C181T polymorphism), one can estimate that under the null hypothesis, one would expect 2.6 and 10.5 interactions to be nominally significant at α = 0.025 and α = 0.10, respectively, by chance alone (as described earlier, these are the two uncorrected significance levels used in the present study).

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