The primary endpoint (composite of death, MI, stroke, leg amputation, acute coronary syndrome, cardiac bypass, or leg revascularization) was reduced by 10% but this did not reach statistical significance because of an increase in leg revascularization (HR 0.90, 95% CI 0.80–1.02; P = 0.095).
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Pioglitazone and alogliptin combination therapy in type 2 diabetes: a pathophysiologically sound treatment.
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0.0950
0.0950