Regarding the protein levels of Hsp70 co-chaperone, these appear to follow a dose-dependent increase, which becomes quite significant in response to relatively high doses of 17-AAG (1 and 10 μΜ) in all three cell lines.
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17-Allylamino-17-demethoxygeldanamycin induces downregulation of critical Hsp90 protein clients and results in cell cycle arrest and apoptosis of human urinary bladder cancer cells.
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