Sequential introduction of single room isolation and hand hygiene campaign in the control of methicillin-resistant Staphylococcus aureus in intensive care unit.

However a significant trend improvement of ICU onset MRSA infection by segmented regression analysis can only be demonstrated when comparison was made before and after the severe acute respiratory syndrome (SARS) epidemic.

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In our previous studies on the molecular epidemiology of blood cultures isolates of MRSA in five hospitals in Hong Kong, including our centre, the MRSA strains related to the CC8/SCC mec III/IIIA had decreased from 81.3% before year 2000 to 26.5% in year 2006 to 2008, whereas the CC45/SCCmec IV/V clone had increased from 16.6% to 42.6% in the corresponding period, which was associated with an increasing trend of MRSA bacteremia from 0.05 per 1000 bed-days in 2004 to 0.09 per 1000 bed-days in 2006-2008 [ 26 , 27 ].

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