Barely Significant
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Effect of allergen-specific immunotherapy with purified Alt a1 on AMP responsiveness, exhaled nitric oxide and exhaled breath condensate pH: a randomized double blind study.

Allergy Asthma Clin Immunol · 2010 · PMC2949816 · PMID 20846390

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However, a decrease in EBC pH was also detected in the placebo group, although it did not reach statistical significance.

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highly significantno p-value reported
The results of our study clearly demonstrate that SIT with purified natural Alt a1 is associated with a highly significant increase in allergen-specific IgG 4 level.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.