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Dietary supplementation of soy germ phytoestrogens or estradiol improves spatial memory performance and increases gene expression of BDNF, TrkB receptor and synaptic factors in ovariectomized rats.

Nutr Metab (Lond) · 2010 · PMC2949863 · PMID 20843342

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showed a trendno p-value reported
All animals showed a trend of spending more time in the target quadrant of the swimming pool.

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