IM plasma levels showed a high inter-patient variability, and low IM plasma exposure (minimum concentration [Cmin] <1100 ng/mL) showed a trend of low rate of objective response and a rapid evolution of resistance (short time to progression).
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IM plasma levels showed a high inter-patient variability, and low IM plasma exposure (minimum concentration [Cmin] <1100 ng/mL) showed a trend of low rate of objective response and a rapid evolution of resistance (short time to progression).