ApoE-/- PGC-1α-/- mice display reduced IL-18 levels and do not develop enhanced atherosclerosis.

PLoS One · 2010 · PMC2962638 · PMID 21042583

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Total plasma cholesterol showed a clear trend, whereas total triglyceride levels were markedly lower in ApoE −/− PGC-1α −/− compared to ApoE −/− PGC-1α +/+ mice ( Fig. 4C ).

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