Diabetic nephropathy is accelerated by farnesoid X receptor deficiency and inhibited by farnesoid X receptor activation in a type 1 diabetes model.

The development of albuminuria in diabetic FXR KO mice was associated with increased diabetes-induced renal hypertrophy compared with wild-type mice, but the difference did not reach statistical significance, as revealed by the kidney-to-body weight ratio ( Table 1 ).

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