The most striking example of an effect that was seen consistently in multiple haplotypic contexts is that of B*3906, which significantly increases the risk of four of five tested haplotypes and shows a nonsignificant trend toward increased risk in the remaining one (DR3).
← all excerpts
HLA class I and genetic susceptibility to type 1 diabetes: results from the Type 1 Diabetes Genetics Consortium.
2
—
—
The sentences
This difference did not reach statistical significance; however, comparison of these two alleles on a single haplotype, DR7, was significant.