Co-evolution of cancer microenvironment reveals distinctive patterns of gastric cancer invasion: laboratory evidence and clinical significance.

With regard to key molecular features in this study, the OS was longer in MMP9 negative group (44.0 months) than in MMP9 positive group (13.5 months) ( P = 0.036), in type IV collagen positive group (25.5 months) than negative group (10.0 months) ( P = 0.044), and in MMP2 negative group (22.0 months) than in MMP2 positive group (14.0 months) ( P = 0.867), although the differences in MMP2 expression did not reach statistical significance.

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