Modulation of thermal stability can enhance the potency of siRNA.

Nucleic Acids Res · 2010 · PMC2978349 · PMID 20610434

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a clear trendno p-value reported

If sense strand cleavage by Ago2 slicer were a critical step in the assembly of the RISC complex, one would expect to observe a strong dependence of the siRNA activity on the resulting non-canonical base pair with a clear trend towards reduced potency.

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