Preliminary studies showed a trend towards weaker response to interferon mono-therapy in the presence of occult HBV.[ 2 , 33 ] However, these were followed by several studies which differed in their views and emphasized a minimal role for occult HBV in occult contamination in response to interferon mono-therapy or its combination with ribavirin.[ 28 , 40 – 43 , 45 ] Due to the differing results obtained in various studies, and the absence of prospective controlled trials, it becomes imperative to perform such trials to clarify the role of occult HBV infection and its impact on anti-HCV treatment.
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Occult hepatitis B infection and its possible impact on chronic hepatitis C virus infection.
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