Endogenous viral elements in animal genomes.

EVEs related to viruses with RNA genomes We identified numerous, highly significant matches (i.e. e-values <1×10 −9 ) to RNA viruses in the genomes of mammals and insect vectors ( Table 1 , Tables S3 , S4 , S5 ).

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This analysis provides more robust support for purifying selection than classical tests based on the ratio of synonymous to non-synonymous mutations (which are weakly significant for EBLN-1 [11] ), strongly indicating that EBLN-1 has been exapted in the primate genome, at least during part of its evolutionary history.

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