Intensive lowering of LDL cholesterol with 80 mg versus 20 mg simvastatin daily in 12,064 survivors of myocardial infarction: a double-blind randomised trial.

When cancer sites were more finely divided, a nominally significant excess of female breast cancer was observed (31 [3·0%] vs 17 [1·7%]; along with four vs one male breast cancers), but that difference is based on small numbers of events and was not significant after appropriate allowance was made for multiple comparisons (as prespecified).

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