Ocular infection of mice with an avirulent recombinant HSV-1 expressing IL-4 and an attenuated HSV-1 strain generates virulent recombinants in vivo.

This difference between mice infected with a mixture of HSV-IL-4 and KOS compared with mice infected with each individual virus was highly significant (p=0.0001, Fisher’s exact test).

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Although this difference did not reach statistical significance, it should be noted that the dbl-IL-4 parent virus DM33, is deleted for γ34.5 and LAT, and neither this virus, nor d34.5, deleted for γ34.5, nor KOS, has ever killed a single mouse or rabbit in our hands.

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